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U-81 may refer to one of the following German submarines:

• 
  SM U-81, a Type U 81 submarine launched in 1916 and that served in the First World War until sunk on 1 May 1917
  
  • During the First World War, Germany also had this submarine with a similar name:
    
    • 
      SM UB-81, a Type UB III submarine launched in 1917 and sunk on 2 December 1917


• 
  German submarine U-81 (1941), a Type VIIC submarine that served in the Second World War until sunk on 9 January 1944; raised on 22 April 1944 and broken up

list of ships with the same or similar names This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.